Since the efficiency of retrieval and query of mass and high-speed space targets remains in a low level, a construction method of sphere grid index to the space targets based on the orbit restraint was proposed. The advantage that the orbit of space target is relatively stable in earth inertial coordinate system was used in the method to achieve the stabilized index to high-speed moving objects by maintaining the list of the space targets that pass through the sphere subdivision grid. On this basis, a region query application scheme was proposed. Firstly, the query time period was dispersed according to a particular step value. Secondly, the boundary coordinates of the query region in the inertial space were calculated and the staggered mesh was confirmed. Then the space targets in the grid were extracted and the spatial relationship between targets and the region was calculated and estimated. Finally, the whole time period was queried recursively and the space targets transit query analysis was accomplished. In the simulation experiment, the consumed time of the traditional method by calculating one by one has a linear positive correlation with the target number, but it has no relevance with the region size. One target costs 0.09 ms on average. By contrast, the time of the proposed method in the paper shows a linear decrease with the decline of area size. When the number of the region grids is less than 2750, the time efficiency is higher than that of the comparison method. Furthermore, it can maintain a fairly good accuracy. The experimental results show that the proposed method can improve the efficiency of the query in the actual region application effectively.